Perform the estimation of mutational signatures associated to prognosis.
associationPrognosis(clinical_data, signatures)
Arguments
- clinical_data
Matrix with two columns proving survival times (first column) and status (second column).
- signatures
Matrix with the estimated exposures to signatures (columns) for each patient (rows).
Value
A vector of coefficients resulting from regularized Cox regression.
Examples
data(association_survival)
set.seed(12345)
clinical_data = association_survival$clinical_data
normalized_alpha = association_survival$normalized_alpha
prognosis_associations = associationPrognosis(clinical_data = clinical_data, signatures = normalized_alpha)